Genz-669178 [CAS 1254834-91-7]

Genz-669178 is an inhibitor for dihydroorotate dehydrogenase (DHODH) with IC50 of 0.015-0.05 μM in Plasmodium spp.. Genz-669178 inhibits P. berghei, P. falciparum strains 3D7 and Dd2 with IC50 of 0.068, 0.008 and 0.01 μM, respectively. Genz-669178 exhibits anti-malarial efficacy in P. berghei-infected mice with ED50 of 13-21 mg/kg/day. Genz-669178 exhibits good pharmacokinetic characteristics in mice[1].

[1254834-91-7]

C17H14N4OS

322.38

O=C(NC1CC1)C2=CC=C(S2)N3C4=CC=CC(C#N)=C4N=C3C

Dihydroorotate Dehydrogenase; Parasite

Room temperature