GGTI-2154 [CAS 251577-10-3]

GGTI-2154 is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM) . GGTI-2154 can be used for the research of cancer[1][2].

[251577-10-3]

C24H28N4O3

420.5

CC(C)C[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CN=CN2)C=C1C3=CC=CC=C3C)=O

Apoptosis

10 mM in DMSO

Room temperature