GGTI-286 (TFA)

Name: GGTI-286 (TFA)
Brand: QuantiMol
SKU: QM-0138650-01
Price: 501.98 GBP
Availability: InStock

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SKU:QM-0138650-01

£501.98 GBP

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Product Details

Description
GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276. GGTI-286 TFA selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 μM, respectively). GGTI-286 TFA also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1][2].
Molecular Formula
C25H32F3N3O5S
Molecular Weight
543.6
Smiles
CC(C)C[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.OC(C(F)(F)F)=O
Target
Others
Purity
92.45
Solubility
10 mM in DMSO
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Shipping Conditions
Room Temperature

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Variant	Variant total	Quantity	Price	Variant total
1 mgQM-0138650-01	1 mgQM-0138650-01 Regular price ~~£334.80~~ Sale price £501.98/ea	£0.00	Quantity	Regular price ~~£334.80~~ Sale price £501.98/ea	£0.00

5 mgQM-0138650-02	5 mgQM-0138650-02 Regular price ~~£855.00~~ Sale price £1,204.25/ea	£0.00	Quantity	Regular price ~~£855.00~~ Sale price £1,204.25/ea	£0.00

10 mgQM-0138650-03	10 mgQM-0138650-03 Regular price ~~£1,395.00~~ Sale price £1,933.25/ea	£0.00	Quantity	Regular price ~~£1,395.00~~ Sale price £1,933.25/ea	£0.00

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GGTI-286 (TFA) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.