GI261520A [CAS 179248-64-7]

GI261520A is a egfr/erbb2 dual inhibitor. GI261520A inhibits PhoQ phosphorylation dose-dependently. GI261520A can downregulate the activity levels of PhoP/PhoQ. GI261520A inhibits pagC reporter expression levels with an IC50 of 3.2 μM. GI261520A inhibits PhoQc autokinase activtiy by 80%. GI261520A can permeate the eukaryotic plasmatic and vascular cell membranes and reach intravacuolar Salmonella to block intramacrophage proliferation[1].

[179248-64-7]

C22H19N3O2

357.41

COC1=CC2=C(NC3=CC=C(C=C3)OCC4=CC=CC=C4)N=CN=C2C=C1

Bacterial; EGFR

Room temperature