GIP (22-51) human [CAS 957470-49-4]

GIP (22-51) human (Glucose-dependent Insulinotropic Peptide (22-51) human) is a potent proatherosclerotic peptide hormone consisting of 30 amino acids. GIP (22-51) human can activate the NF-κB signaling pathway, promote the expression of MMP-8, and induce the expression of proinflammatory and proatherosclerotic proteins. GIP (22-51) human can also increase the level of intracellular free Ca2+ in THP-1-induced macrophages. GIP (22-51) human can be used in the research of atherosclerosis[1].

[957470-49-4]

C140H226N44O41

3181.56

O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CC(C)C)C(N3[C@@H](CCC3)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N4[C@@H](CCC4)C(N[C@@H](C(C)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC5=CNC=N5)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N6[C@@H](CCC6)C(N[C@@H](CCC(N)=O)C(N7[C@@H](CCC7)C(N[C@@H](CCCNC(N)=N)C(NCC(N8[C@@H](CCC8)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N

Calcium Channel; MMP; NF-κB

MMP-8

Room temperature