GL392

GL392 is a senolytic agent that selectively delivers the potent senolytic compound Dasatinib to senescent cells. GL392 targets lipofuscin in senescent cells via the LBD domain and is linked to Dasatinib through an ester bond. Upon internalization in senescent cells, Dasatinib is released, inducing apoptosis of the senescent cells. Additionally, GL392 is encapsulated in PEO-b-PCL micelles to ensure effective intracellular delivery and minimize systemic toxicity. GL392 can be used in cancer research applications.

C55H52ClN13O5S

1042.6

CC1(COC(CCC(OCCN2CCN(C3=CC(NC4=NC=C(C(NC5=C(C)C=CC=C5Cl)=O)S4)=NC(C)=N3)CC2)=O)=O)NC6=CC=CC(C6=C(N1)C=C7)=C7/N=N/C(C=C8)=C9C(C=CC=C9)=C8/N=N/C%10=CC=CC=C%10

Apoptosis

Room temperature