Glasdegib-d4

Glasdegib-d4 (PF-04449913-d4) is deuterium labeled Glasdegib. Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM[1][2].

C21H18D4N6O

378.46

CN1[C@H](C[C@@H](CC1)NC(NC2=C([2H])C([2H])=C(C([2H])=C2[2H])C#N)=O)C3=NC4=CC=CC=C4N3

Isotope-Labeled Compounds; Smo

Room temperature