Gliotoxin [CAS 67-99-2]

Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells [1]. Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis[2]. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells[3]. Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells[4].

[67-99-2]

C13H14N2O4S2

326.39

O=C1N([C@]2(C(N3[C@]1(CC4=CC=C[C@@H]([C@@]34[H])O)SS2)=O)CO)C

Antibiotic; Apoptosis; Bacterial; Fungal; NF-κB; PKA

99.51

DMF : 5 mg/mL (ultrasonic; warming) |DMSO : 5 mg/mL (ultrasonic; warming)

-20°C, 3 years (Powder)

Blue Ice

H301

H301