β-Glu-PAB (CH2NH2) -Exatecan [CAS 3025108-11-3]

β-Glu-PAB (CH2NH2) -Exatecan (Compound 9a) is a topoisomerase I inhibitor. β-Glu-PAB (CH2NH2) -Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. β-Glu-PAB (CH2NH2) -Exatecan can be specifically cleaved by β-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. β-Glu-PAB (CH2NH2) -Exatecan is also an intermediate of Mal ((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12) -β -Glu-Pab-Exatecan. β-Glu-PAB (CH2NH2) -Exatecan is promising for research of cancers[1].

[3025108-11-3]

C39H39FN4O13

790.74

NCC(C=C1COC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=C(C=C1)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O

Topoisomerase

Topoisomerase

96.6

DMSO : 100 mg/mL

-20°C (Powder, stored under nitrogen)

Blue Ice