Glucocorticoid receptor/IL-6-IN-1 [CAS 1198784-71-2]

Glucocorticoid receptor/IL-6-IN-1 (Compound 35) is a selective dual inhibitor targeting the glucocorticoid receptor (GR) and IL-6 signaling pathway (IC50 values of 120 nM and 59 nM, respectively) . Glucocorticoid receptor/IL-6-IN-1 inhibits IL-6-induced JAK/STAT3 phosphorylation, blocking inflammatory cytokine transcription. Glucocorticoid receptor/IL-6-IN-1 is promising for research of inflammatory diseases like rheumatoid arthritis and asthma[1].

[1198784-71-2]

C22H23F4N3O4S

501.49

O=C(C1=CC(F)=CC=C1C(C)(CC(CC2=CC3=C(N2)C=NC(S(=O)(C)=O)=C3)(C(F)(F)F)O)C)N

Glucocorticoid Receptor; Interleukin Related; JAK; STAT

IL-6; STAT3

Room temperature