α-glucosidase/PTP1B-IN-1

α-glucosidase/PTP1B-IN-1 (compound 8a) is a potent α-glucosidase and PTP1B inhibitor with an IC50 value of 66.3 μM and 47.0 μM, respectively. α-glucosidase/PTP1B-IN-1 exhibits excellent activities against α-amylase with an IC50 of 30.62 μM. α-glucosidase/PTP1B-IN-1 can dock into the active pockets of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 has potential to reduce the postprandial blood glucose and is used for Type 2 diabetes mellitus[1].

C23H20Cl2O5

447.31

ClC1=CC(Cl)=C(/C=C/C(OCCOC2=CC(C)=C3C(OC(C(C)=C3C)=O)=C2)=O)C=C1

Amylases; Glycosidase; Phosphatase

Room temperature