Gly-Cyclopropane-Exatecan [CAS 2414254-49-0]

Gly-Cyclopropane-Exatecan involves in the synthesis of anti-B7-H4 ADC, containing Exatecan , a DNA Topoisomerase I inhibitor. Gly-Cyclopropane-Exatecan participated in the formation of the ADC hu2F7-Exatecan (compound 34), which showed antitumor activity in vivo and in vitro[1].

[2414254-49-0]

C32H34FN5O7

619.64

NCC(NCOC(C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O

ADC Payload; Topoisomerase

Camptothecins

10 mM in DMSO

Room temperature