GNE-1567

GNE-1567 is a potent ERα PROTAC degrader and a selective XIAP antagonist with a Kd value of 0.03 μM. GNE-1567 is indicated for breast cancer research. (Pink: ligand for target protein ; Black: linker; Blue: ligand for E3 ligase (HY-175449) ).

C60H65BrN6O9

1094.1

CC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(C=C3)OCCN(C(CCOCCOCCC(N4C5=C(N(C([C@H]([C@@H]4C)NC([C@@H](NC)C)=O)=O)CC6=C(C=CC7=C6C=CC(Br)=C7)OC)C=CC(C#N)=C5)=O)=O)C

Estrogen Receptor/ERR; IAP; PROTACs

XIAP

Room temperature