GNE-5152 [CAS 3080315-83-6]

GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research[1].

[3080315-83-6]

C21H17F2N3O

365.38

O=C1N(CCC(C1)C2=CC=C(C(F)=C2)F)C3=CC=C(C4=CC=NC=C4)N=C3

Toll-like Receptor (TLR)

Room temperature