GNF179 (Metabolite) [CAS 1310455-86-7]
GNF179 (Metabolite) [CAS 1310455-86-7]
SKU:QM-0000598
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Product Details
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Description
GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency (4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. IC50 value: Target: Anti-parasitic agent GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours) . GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not.
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CAS Number
[1310455-86-7]
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Molecular Formula
C14H16FN3
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Molecular Weight
245.3
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Smiles
CC1(C2=NC(C3=CC=C(F)C=C3)=CN2CCN1)C
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Target
Parasite
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Isoform
Plasmodium
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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GNF179 (Metabolite) [CAS 1310455-86-7]
GNF179 (Metabolite) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.