Gonyautoxin III [CAS 60537-65-7]

Gonyautoxin III (GTX-III) is a paralytic shellfish poisoning toxin. Gonyautoxin III can block of the voltage-gated sodium channels at axonal level with an IC50 of 14.9 nM, impeding nerve impulse propagation. Gonyautoxin III has killing activity against mouse neuroblastoma cells. Gonyautoxin III can be used for the researches of cancer and neurological disease[1][2].

[60537-65-7]

C10H17N7O8S

395.35

OC1([C@]23[C@](N=C(N3)N)([H])[C@@H](N=C(N2C[C@@H]1OS(=O)(O)=O)N)COC(N)=O)O

Sodium Channel

Room temperature

H300+H310

P262-P264-P270-P280-P302+P352-P330-P361+P364-P405-P501