GPX4-IN-17 [CAS 3035800-33-7]

GPX4-IN-17 (Compound 9i) is an inhibitor of GPX4 with potent cytotoxicity (IC50 = 0.3 nM) . GPX4-IN-17 shows strong binding affinity against GPX4 (KD = 20.4 nM) . GPX4-IN-17 inhibits tumor growth in the xenograft tumor mouse model without detectable cytotoxicity. GPX4-IN-17 can enhance cancer chemotherapy and overcome tumor resistance. GPX4-IN-17 can be studied in antitumor reseach[1].

[3035800-33-7]

C29H24N4O3S2

540.66

O=C(C1=CSC(C#C)=N1)N(C(C2=CSC3=CC=CC=C32)C(NC(C)(C)C)=O)C4=CC=C(C5=CN=CO5)C=C4

Glutathione Peroxidase

GPX4

Room temperature