GPX4-IN-7

GPX4-IN-7 (Compound 31), indirubin derivative, is a ferroptosis inducer for colon cancer. GPX4-IN-7 has strong antitumor activity against HCT-116 cells with an IC50 value of 0.49 μM. GPX4-IN-7 can promote the degradation of GPX4, causing the accumulation of lipid ROS to induce ferroptosis[1].

C25H23ClN4O4

478.93

O=C(NCC1CCN(CC1)C(CCl)=O)C(C=C2C/3=O)=CC=C2NC3=C4C(C=CC=C5)=C5NC\4=O

Ferroptosis

10 mM in DMSO

Room temperature