GR-28

GR-28 is an inhibitor for small C-terminal domain phosphatase 1 (SCP1) . GR-28 inhibits the transcriptional activity of repressor element-1 silencing transcription factor (REST), inhibits the proliferation of glioblastoma cells (IC50 is 2.9 and 10.1 µM, for cells A172 and T98G) [1].

C26H24N2O5S

476.54

O=C(NCCCNC(C1=CC=C(C2=CC=CC=C2OC)C=C1)=O)C3=CC4=CC=CC=C4S3(=O)=O

Phosphatase

Room temperature