GRL-03022

GRL-03022 is a potent, selective and non-covalent G protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 60 nM. GRL-03022 exhibits >16000-fold selectivity over GRK2 (IC50 > 1000 μM) . GRL-03022 can be used for heart failure and cancer research[1].

C29H32N4O4

500.59

O=C(C1=CC2=C(NC(/C2=C\C3=C(C)C(C(N[C@@H](C)COC)=O)=C(C)N3)=O)C=C1)N[C@@H](C4=CC=CC=C4)C

G Protein-coupled Receptor Kinase (GRK)

GRK2; GRK5

Room temperature