GRL-07524

GRL-07524 (Compound 4e) is a potent inhibitor of HIV-1 protease (Ki = 0.22 nM) . GRL-07524 contains oxaspirocyclic carbamates as the P2 ligands. GRL-07524 exhibits good antiviral activity with an EC50 = 210 nM. GRL-07524 binds to the HIV-1 PR active site in one of the four symmetry independent molecules along with key catalytic residues[1].

C38H50N2O8S

694.88

COC1=CC=C(C=C1)S(=O)(N(CC(C)C)C[C@@H](O)[C@@H](NC(O[C@H]2CCC[C@@]23C[C@@H](C4=C(C=CC=C4)OC)OCC3)=O)CC5=CC=CC=C5)=O

HIV Protease

Room temperature