Groenlandicine [CAS 38691-95-1]

Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor (AChE (IC50 = 0.54 μM), BChE (IC50 = 3.32 μM) ). Groenlandicine non-competitively inhibits BACE1 (IC50 = 19.68 μM, Ki = 21.2) and inhibits RLAR (IC50 = 140.1 μM), HRAR (IC50 = 154.2 μM), and total ROS generation (IC50 = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin. Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus[2][3][4][5].

[38691-95-1]

C19H16NO4+

322.34

COC1=CC2=C(C=C1O)CC[N+]3=CC4=C(C=CC5=C4OCO5)C=C23

Apoptosis; Beta-secretase; Cholinesterase (ChE) ; Reactive Oxygen Species (ROS) ; Topoisomerase

Topo I

99.87

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

4°C (Powder, protect from light)

Room Temperature

H302, H315, H319, H335

H302, H315, H319, H335