GS-8873 (TFA) [CAS 2241575-60-8]

GS-8873 TFA is the TFA salt form of GS-8873. GS-8873 TFA is an orally active inhibitor for the production of hepatitis B virus (HBV) surface antigen (HBsAg) with an EC50 of 4 nM. GS-8873 TFA exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 TFA causes neurofunctional deficits in rats and cynomolgus monkeys[1][2].

[2241575-60-8]

C26H31F3N2O8

556.53

OC(C(F)(F)F)=O.COCC1=C(OCCCOC)C=C([C@]2([H])N(C(C)(CC2)C)N3C4=CC(C(C(O)=O)=C3)=O)C4=C1

HBV

10 mM in DMSO

Room temperature