GSK-1482160 (isomer) [CAS 1695551-19-9]
GSK-1482160 (isomer) [CAS 1695551-19-9]
SKU:QM-0060370
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Product Details
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Description
GSK-1482160 isomer is the isomer of GSK-1482160. GSK-1482160 is an orally active and blood-brain barrier penetrant P2X7 receptor (P2X7R) negative allosteric modulator with pIC50s of 8.5 (human) and 6.5 (rat). GSK-1482160 reduces the efficacy of ATP at the P2X7 receptor without affecting its affinity, thereby inhibiting the release of IL-1β. GSK-1482160 is an effective radioligand and can be labeled with radioactive isotopes like 11C or 18F to image P2X7R. GSK-1482160 can be used for the studies of chronic joint pain and chronic constriction injury (CCI).
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CAS Number
[1695551-19-9]
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Molecular Formula
C14H14ClF3N2O2
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Molecular Weight
334.72
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Smiles
ClC1=C(C(F)(F)F)C=CC=C1CN(C)C([C@@H]2CCC(N2)=O)=O
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Target
Drug Isomer
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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GSK-1482160 (isomer) [CAS 1695551-19-9]
GSK-1482160 (isomer) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.