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GSK-3α/β-IN-1 [CAS 1574354-24-7]
GSK-3α/β-IN-1 [CAS 1574354-24-7]
SKU:QM-0010768
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Product Details
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Description
GSK-3α/β-IN-1 is GSK-3α/β inhibitor with IC50 s of 0.265 μM and 0.255 μM for GSK-3α and GSK-3β, respectively. GSK-3α/β-IN-1 also inhibits PKA with an IC50 of 0.188 μM. GSK-3α/β-IN-1 potently inhibits cell viability of three Glioblastoma (GBM) cell lines (IC50 : 3-6 μM, 72 h) with no toxicity to human astrocytes and good metabolic stability. GSK-3α/β-IN-1 has potential CNS activity in all-human blood-brain barrier (BBB) model of GBM[1].
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CAS Number
[1574354-24-7]
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Molecular Formula
C21H17N3O2
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Molecular Weight
343.38
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Smiles
OC1=CC=C(C2=NC(NN=C3)=C3C(C4=CC=C(C(C)C)C=C4)=C2O5)C5=C1
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Target
GSK-3; PKA
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Isoform
GSK-3α; GSK-3β; PKA
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Shipping Conditions
Room temperature
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GSK-3α/β-IN-1 [CAS 1574354-24-7]
GSK-3α/β-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.