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GSK143 [CAS 1240390-27-5]
GSK143 [CAS 1240390-27-5]
SKU:QM-0061006
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Product Details
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Description
GSK143 is an orally active and highly selective spleen tyrosine kinase (SYK) inhibitor with a pIC50 of 7.5. GSK143 inhibits phosphorylated Erk (pErk: pIC50=7.1) [1]. GSK143 reduces inflammation and prevents recruitment of immune cells in the intestinal muscularis in mice[2][3].
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CAS Number
[1240390-27-5]
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Molecular Formula
C17H22N6O2
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Molecular Weight
342.4
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Smiles
O=C(C1=CN=C(N[C@H]2[C@@H](N)COCC2)N=C1NC3=CC=C(C)C=C3)N
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Target
ERK; Syk
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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GSK143 [CAS 1240390-27-5]
GSK143 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.