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GSK235
GSK235
SKU:QM-0016175
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Product Details
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Description
GSK235 is an orally active, selective and allosteric endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor with pIC50 values of 8.45 and 7.59 for human and mouse ERAP1, respectively. GSK235 exhibits over 1000-fold selectivity for the two most homologous enzymes, ERAP2 and IRAP. GSK235 can regulate the immunopeptidome of cancer cells and enhance cancer cell antigenicity. GSK235 can be used for the study of colorectal cancer and arthritis[1].
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Molecular Formula
C21H30N4O3
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Molecular Weight
386.49
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Smiles
CC1=C(C#N)C(N2C[C@H](C(C)C)[C@@H](C(O)=O)C2)=NC(NC3(C)CCOCC3)=C1
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Target
Aminopeptidase
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Shipping Conditions
Room temperature
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GSK235
GSK235 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.