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GSK3β-IN-2 [CAS 3068378-38-8]
GSK3β-IN-2 [CAS 3068378-38-8]
SKU:QM-0010310-01
£401.13 GBP
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Product Details
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Description
GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model[1].
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CAS Number
[3068378-38-8]
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Molecular Formula
C25H18N4O
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Molecular Weight
390.44
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Smiles
O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=CC=C5)C=CN=C4
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Target
GSK-3; Wnt; β-catenin
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Isoform
GSK-3β
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Concentration
10mM
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Purity
98.75
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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GSK3β-IN-2 [CAS 3068378-38-8]
GSK3β-IN-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.