GSK3494245 [CAS 2080410-41-7]
GSK3494245 [CAS 2080410-41-7]
SKU:QM-0142152-01
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Product Details
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Description
GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L. donovani proteasomes) . GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 μM; enriched THP-1 extracts IC50=40μM) . GSK3494245 exhibits attractive biological and biosafety properties[1][2].
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CAS Number
[2080410-41-7]
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Molecular Formula
C21H23FN6O2
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Molecular Weight
410.44
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Smiles
O=C(N1CCCC1)NC2=CC=C(F)C(C3=NC4=NC=C(N5CCOCC5)N4C=C3)=C2
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Target
Parasite; Proteasome
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Purity
98.66
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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GSK3494245 [CAS 2080410-41-7]
GSK3494245 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.