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GSK761
GSK761
SKU:QM-0149780-01
£527.50 GBP
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Product Details
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Description
GSK761 is a selective inhibitor of speckled 140 kDa (SP140) with an IC50 value of 77.79 nM. GSK761 reduces monocyte-to-inflammatory macrophage differentiation and lipopolysaccharide (LPS) -induced inflammatory activation. GSK761 induces the production of CD206+ regulatory macrophages by inhibiting SP140[1].
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Molecular Formula
C40H46N4O4
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Molecular Weight
646.82
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Smiles
CN1C2=CC=C(C=C2N=C1C3=CC=C(C=C3)C(NC4=CC(CCOC(C)(C)C)=CC=C4)=O)C(NC5=CC(CCOC(C)(C)C)=CC=C5)=O
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Target
Epigenetic Reader Domain
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Concentration
10mM
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Purity
99.42
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Solubility
DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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GSK761
GSK761 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.