GSPT1 degrader-16 [CAS 3060504-68-6]

GSPT1 degrader-16 (Compound Lib-B-18J) is a potent and selective cereblon-based molecular glue degrader that targets G1 to S phase transition 1 (GSPT1) . GSPT1 degrader-16 shows inhibitory effect to RS4;11, Molt4, and MM.1S cells with IC50 values of 0.002, 0.26 and 0.37 μM. GSPT1 degrader-16 can be used for the research of cancer, such as acute lymphoblastic leukemi[1].

[3060504-68-6]

C36H30N6O5

626.66

O=C(N/N=C/C1=NN(C2=C1C=CC=C2)CC3=CC=CC=C3)COC4=CC=CC=C4C5=C6C(C(N(C6)C7C(NC(CC7)=O)=O)=O)=CC=C5

Molecular Glues

Room temperature