GSPT1 degrader-9 [CAS 3034310-17-0]

GSPT1 degrader-9 (Compound F) is a cereblon-based molecular glue degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM) . GSPT1 degrader-9 inhibits the cell viability of HL-60 with an IC50 of 9.2 nM[1].

[3034310-17-0]

C37H36ClN7O5

694.18

O=C1NC(C(CC1)N2C(C3=CC=C(N4CC(CCN5C(N(CCC5)C6=CC(C7=C(Cl)C8=C(NC=C8CC)N=C7)=CC=C6)=O)C4)C=C3C2=O)=O)=O

Molecular Glues

Room temperature