Guaiol [CAS 489-86-1]

Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions[1][2][3][4][5][6].

[489-86-1]

C15H26O

222.37

C[C@@H]1C2=C([C@H](CC[C@@H](C(C)(O)C)C2)C)CC1

Autophagy; RAD51

99.67

DMSO : 33.33 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335