Guttiferone G [CAS 666174-75-0]

Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively) . Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL) . Guttiferone G can be isolated from Garcinia macrophylla[1][2].

[666174-75-0]

C43H58O6

670.92

C/C(C)=C/C[C@](C([C@]12C/C=C(C)/C)=O)(C(C(C(C(C=C3)=CC(O)=C3O)=O)=C1O)=O)[C@](C)([C@@H](C2)C/C=C(C)/CC/C=C(C)/C)CC/C=C(C)/C

Sirtuin

10 mM in DMSO

Room temperature