GZD856 (formic) [CAS 2804039-78-7]

GZD856 formic is a potent and orally active PDGFRα/β inhibitor, with IC50s of 68.6 and 136.6 nM, respectively. GZD856 formic is also a Bcr-AblT315I inhibitor, with IC50s of 19.9 and 15.4 nM for native Bcr-Abl and the T315I mutant. GZD856 formic has antitumor activity[1][2]. GZD856 (formic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

[2804039-78-7]

C30H29F3N6O3

578.58

O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN5C(N=C4)=CC=N5)=C3.OC=O

Apoptosis; Bcr-Abl; PDGFR

Bcr-Abl; PDGFRα; PDGFRβ

95.36

DMSO : 100 mg/mL (ultrasonic)

-20°C (Powder, sealed storage, away from moisture)

Blue Ice