HA-9104 [CAS 2412367-83-8]

HA-9104 is a potent and selective inhibitor of cullin-5 neddylation via virtually targeting the V30 pocket of UBE2F. HA-9104 binds to UBE2F, reduces its protein levels, and consequently inhibits cullin-5 neddylation. HA-9104 has potent growth suppression and radiosensitizing activities via targeting the UBE2F-CRL5 axis and causing DNA damage, leading to induction of apoptosis and G2/M arrest in lung and pancreatic cancer cells[1].

[2412367-83-8]

C28H27N5O2

465.55

O=C(NC1=CC=C(N2CCN(CC2)C(C3=CC=C(C)C=C3)=O)C=C1)/C=C/C4=CNC5=C4C=CC=N5

Apoptosis; E1/E2/E3 Enzyme

98.54

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature