HAChE/hBACE-1-IN-4 [CAS 229476-71-5]

HAChE/hBACE-1-IN-4 (compound AK-2) is a quinazoline derivative. hAChE/hBACE-1-IN-4 shows significant inhibitory activity against hAChE and hBACE-1 enzymes (hAChE, IC50=0.283 μM; hBACE-1, IC50=0.231 μM) . hAChE/hBACE-1-IN-4 has the potential to inhibit Aβ aggregation. hAChE/hBACE-1-IN-4 has non-neurotoxicity , blood-brain barrier permeability and oral activity. hAChE/hBACE-1-IN-4 can be used in Alzheimer's disease research[1].

[229476-71-5]

C21H24N4O2

364.44

COC1=C(OC)C=C2C(N(CC3)CCN3CC4=CC=CC=C4)=NC=NC2=C1

Amyloid-β; Cholinesterase (ChE)

AChE; BChE

10 mM in DMSO

Room temperature