Harmane-d2

Harmane-d2 is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM) . Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively) [1][2][3][4].

C12H8D2N2

184.23

CC1=NC([2H])=C([2H])C2=C1NC3=C2C=CC=C3

Adrenergic Receptor; Imidazoline Receptor; Isotope-Labeled Compounds; Monoamine Oxidase

10 mM in DMSO

Room temperature