HCAI/II-IN-3 [CAS 2480283-93-8]

HCAI/II-IN-3 (compound 5b) is a potent dual hCA I/II inhibitor with Ki values of 51.25, 13.15 and 42.18 nM for hCA I, hCA II and hCA IX. hCAI/II-IN-3 possesses anti-hypoxic activity against acute mountain sickness (AMS) and low cellular activity[1].

[2480283-93-8]

C16H18N4O4S2

394.47

O=C(C1=CSC(NC(C2=CC=C(S(=O)(N)=O)C=C2)=O)=N1)NC3CCCC3

Carbonic Anhydrase

CA II; CA I

10 mM in DMSO

Room temperature