HCAI/II-IN-8 [CAS 3036136-18-9]

HCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC50 = 21.35 ± 0.39 nM (hCA I) ; 7.12 ± 0.12 nM (hCA II) ) . hCAI/II-IN-8 inhibits AChE and BChE as well (IC50 = 46.27 ±0.75 nM (AChE) ; 43.38 ± 0.83 nM (BChE) ) . [1].[1].

[3036136-18-9]

C22H20N4O3

388.42

CN(C)C1=CC=C(C(OC2=CC=C(/C=N/NC(C3=CN=CC=C3)=O)C=C2)=O)C=C1

Carbonic Anhydrase; Cholinesterase (ChE)

AChE; BChE; CA II; CA I

10 mM in DMSO

Room temperature