HCAII-IN-10

HCAII-IN-10 (compound 11d) is hCA II inhibitor with the IC50s of 14 nM and 29.2 μM for hCA II and hCA I, respectively. hCAII-IN-10 inhibits cell growth against HT-29 cells with the IC50 of 74 μM. hCAII-IN-10 shows strongly lowered intraocular pressure in the glaucomatous rabbit eye model[1].

C13H21N5O7S

391.4

O[C@@H]1[C@@H](CO)O[C@H](NNC(NC2=CC=C(S(N)(=O)=O)C=C2)=O)[C@H](N)[C@H]1O

Carbonic Anhydrase

CA II; CA I

10 mM in DMSO

Room temperature