HDHODH-IN-10 [CAS 3033087-05-4]

HDHODH-IN-10 is a selective, potent and orally active hDHODH inhibitor, with an IC50 value of 10.9 nM. hDHODH-IN-10 forms hydrogen bonds with key residues Arg136 and Gln47. hDHODH-IN-10 inhibits the proliferation of cancer cells. hDHODH-IN-10 can be used in the research of cancers, such as AML, colorectal cancer[1].

[3033087-05-4]

C21H15ClF4N2O4

470.8

C/C(O)=C(C(NC1=C(C=C(C(O[C@H](C(F)(F)F)C)=C1)C(C2=C(C=CC=C2)Cl)=O)F)=O)\C#N

Dihydroorotate Dehydrogenase

10 mM in DMSO

Room temperature