HDM-IN-1 [CAS 3020690-76-7]

HDM-IN-1 (Compound A4) is an inhibitor for fungal histone demethylase (HDM), that inhibits the H3K27me3 in Cryptococcus neoformans and in Candida auris with IC50s of 134 and 12 nM. HDM-IN-1 exhibits inhibitory efficacy against C. neoformans and C. auris with MIC80 of 0.5-2 μg/mL, through inhibition of the biofilm and capsule formation. HDM-IN-1 exhibits antifungal activity in ICR mouse model[1].

[3020690-76-7]

C17H15N5O

305.33

COC(C=C1)=CN=C1N/N=C(C2=NC=CC=C2)\C3=NC=CC=C3

Fungal; Histone Demethylase

Room temperature