Henatinib [CAS 1239269-51-2]

Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity of VEGFR-2, c-kit, PDGFR with IC50 values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs) [1].

[1239269-51-2]

C25H29FN4O4

468.52

O=C1N(C[C@H](O)CN2CCOCC2)CCCC3=C1C(C)=C(/C=C4C(NC5=C\4C=C(F)C=C5)=O)N3

C-Kit; PDGFR; VEGFR

PDGFRα; PDGFRβ; VEGFR2/KDR/Flk-1

10 mM in DMSO

Room temperature