Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively. Hex is a NfENO and TbENO inhibitor with IC50s value of 0.14 μM and 2.1 μM, respectively. Hex has antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites and Plasmodium berghei ANKA strain. Hex has anti-tumor effects against intracranial tumors[1][2][3][4][5][6][7][8].
CAS Number
[2004714-32-1]
Molecular Formula
C5H10NO5P
Molecular Weight
195.11
Smiles
OP(O)(C1C(N(O)CCC1)=O)=O
Target
Enolase; Parasite
Purity
99.96
Solubility
DMSO : 140 mg/mL (ultrasonic)
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)