Hibarimicin B [CAS 151687-86-4]

Hibarimicin B (Angelmicin B) is a tyrosine kinase inhibitor. It selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. It also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL[1].

[151687-86-4]

C85H112O37

1725.78

[H]C1([C@@](C2=C(C3=C(C(O)=C2C4=O)C(C(C(C(O)=C56)=C(OC)C(OC)=C6C=C7C[C@]8([C@H]([C@@H]([C@H]([C@](CCC)([C@](O)8C(C7=C5O)=O)O)O[C@H]9CC[C@@H]([C@H](O9)C)O[C@H]%10CC[C@@](C(C)=O)([C@@H](O%10)C)O)O)O[C@H]%11O[C@@H]([C@H]([C@H](C%11)O)O)C)[H])=C(C3=O)OC)=O)O)(O[C@]%12(CCC)[C@@]41O)[H])[C@@H](O[C@H]%13O[C@@H]([C@H]([C@H](C%13)O)O)C)[C@H](O)[C@H]%12O[C@H]%14CC[C@@H]([C@H](O%14)C)O[C@H]%15CC[C@@](C(C)=O)([C@@H](O%15)C)O

Bacterial; Src

Room temperature