HIF-1α-IN-8

HIF-1α-IN-8 is an orally active HIF-1α inhibitor, with an IC50 of 2.02 μM. HIF-1α-IN-8 significantly suppresses the expression of inflammation factors of IL-6 and NO, reduces hypoxia-induced ROS production and apoptosis in C8-D1A cells. HIF-1α-IN-8 inhibits HIF-1α/IKKα/NF-κB signaling pathway and reduces the expression of blood-brain barrier permeability-related proteins. HIF-1α-IN-8 reduces brain water content and oxidative stress level in mice with high altitude cerebral edema (HACE) model. HIF-1α-IN-8 can be used for the study of high altitude cerebral edema (HACE) [1].

C29H30FNO7

523.55

O=C(NC1=CC=C(C2=CC=C(CCO[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=C2)C=C1)/C=C/C4=CC=CC=C4F

Apoptosis; HIF/HIF Prolyl-Hydroxylase; IKK; NF-κB; Reactive Oxygen Species (ROS)

HIF-1α; IKK-α

Room temperature