HINT1-IN-1

HINT1-IN-1 (Compound 8) is the inhibitor for histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. HINT1-IN-1 affects the cross-regulation between μ-opioid receptor (MOR) and NMDA receptor (NMDAR) . HINT1-IN-1 enhances the analgesic effect of morphine without causing opioid tolerance and has independent analgesic effects in mouse model[1].

C23H24N8O5

492.49

O=C(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)N3C4=NC=C3)=C4N=C2)O1)NCCC5=CNC6=C5C=CC=C6

Opioid Receptor

Room temperature