HMcl-1-IN-1

HMcl-1-IN-1 (Compound 9) is an hMcl-1 inhibitor based on His224 aryl sulfonate fluoride, with an IC50 value of 5.8 nM[1].

C69H113FN20O19S

1577.82

NC([C@H](CC1=CC=C(C=C1)OS(=O)(F)=O)NC([C@@H](NC([C@H](CC(O)=O)NC(CNC([C@@]([H])(NC([C@]2(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@](C)(CCC/C=C\CCC2)NC([C@H](C)NC([C@@]([H])(NC(C)=O)[C@H](CC)C)=O)=O)=O)CCC(N)=O)=O)CC(C)C)=O)CCCNC(N)=N)=O)C)=O)[C@H](CC)C)=O)=O)=O)CCCNC(N)=N)=O)=O

Bcl-2 Family

Room temperature