HNMPA- (AM) 3 [CAS 120944-03-8]

HNMPA- (AM) 3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA- (AM) 3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA- (AM) 3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively) [1][2].

[120944-03-8]

C20H23O10P

454.36

CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O

Insulin Receptor

98.04

DMSO : ≥ 100 mg/mL

4°C (Powder, sealed storage, away from moisture and light)

Room Temperature

H225, H319

H225, H319